1-(lower alkoxy-phenyl)-2-(lower alkyl-amino)- alkanones-(1) and salts



United States Patent O B 7 Int. Cl. C07c 95/08, 49/76; A61k 27/00 US. Cl. 260570.5 Claims ABSTRACT OF THE DISCLOSURE 1 (lower alkoxy-phenyl) 2 (lower alkyl-amino)-alkanones-(l) and acid addition salts thereof, useful as central nervous system stimulants in warm-blooded animals.

This is a continuation-in-part of copending application Ser. No. 444,038, filed Mar. 30, 1965 and now abandoned.

This invention relates to novel a-amino-substituted (lower alkoxy-phenyl)-alkanones and acid addition salts thereof, as well as to various methods of preparing these compounds.

More particularly, the present invention relates to racemic mixtures of compounds of the formula wherein R is straight-chain alkyl of 2 to 6 carbon atoms,

R is hydrogen or straightor branched-chain lower alkyl, R is straightor branched-chain lower alkyl, and

R is lower alkoxy,

an optically active antipode component thereof, or nontoxic, pharmacologically acceptable acid addition salts of said racemic mixture or of said optically active antipode.

The free base compounds according to the present invention, that is, those embraced by Formula I above, may be prepared by a variety of methods involving well known chemical principles, among which the following have been found to be most convenient and eflicient:

METHOD A (1) By reacting an a-halo-substituted (lower alkoxyphenyl)-alkanone of the formula Hal (II) wherein R and R have the same meanings as in Formula I and Hal is a halogen, with a primary or secondary amine of the formula R (III) wherein R and R have the same meanings as in Formula I.

The reaction is preferably carried out in the presence of an inert organic solvent, such as benzene or ethanol, and at a temperature below 100 C. It is preferred to provide a substantial excess of the amine 111 over and above the stoichiometric amount required for reaction with compound II in order to tie up or neutralize the hydrogen halide released by the reaction. However, an inorganic base or another organic base may be added to the reaction mixture for the same purpose.

The reaction mixture may be worked up in customary fashion; for instance, by dissolving the reaction product in ether and precipitating it from solution as hydrohalide addition salt.

(2) An alternative variation of the method described in 1) above is the reaction of an a-halo-alkanone of the Formula II with the potassium salt of a phenyl-sulfonic acid alkylamide, preferably with the potassium salt of a toluenesulfonic acid alkylamide of the formula III CH R3NS 02 1'1 wherein R and R have the same meanings as in Formula I and A is lower alkyl, and subsequently reacting the intermediate product with a primary or secondary amine of the Formula III. The reaction mixture is then worked up as described in (1).

METHOD B By alkylating a 1 (lower alkoxy-phenyl)-2-aminoalkanone-(l) of the formula wherein R R and R have the same meanings as in Formula I, with an alkylating agent of the formula /X or Ra-Y R (VII) wherein R has the same meanings as in Formula I, R is lower alkyl, Y is halogen, benzene-sulfonyl, toluenesulfonyl or the like, and X is sulfate or the like. The alkylating reaction is preferably carried out in the presence of a compound capable of tying up or neutralizing the acid released by the reaction, such as an alkali metal or an alkali metal alcoholate, and advantgeously in aqueous suspension or in the presence of an inert organic solvent. The amino group may also be methylated with a mixture of formaldehyde and formic acid.

3 METHOD By converting the tertiary amino group of a l-(lower alkoxy-phenyl)-2-amino-alkanone-(1) of the formula wherein R R and R have the same meanings as in Formula I and R is a substituent which can be readily split off, into a secondary amino group (NHR Examples of substituents which may readily be split olf include acyl and aralkyl substituents, especially carbobenzoxy and benzyl. In the event that R is aralkyl, such as benzyl, the conversion of R into hydrogen may, for example, be effected by selective hydrogenation with palladium chloride/ animal charcoal in the presence of ethanol. If R is acyl, such as carbobenzoxy, its removal may be effected in conventional fashion, such as by hydrogenation or hydrolysis, provided the conditions are sufficiently mild.

METHOD D By oxidizing a (lower alkoxy-phenyl)-a-aminoalkanol of the formula @CH-CH-Ri R2 R3 wherein R R R and R have the same meanings as in Formula I, with an oxidizing agent, such as chromic acid or an alkali metal dichromate. The oxidation reaction, which proceeds readily at room temperature or slightly elevated temperatures, may be performed in the presence of an aqueous solvent at an acid pH.

METHOD E By reacting a compound of the formula Z-CHR1 wherein Z is an unsubstituted or substituted carboxamide group or cyano and R and R have the same meanings as in Formula I, and R is lower alkyl, with a compound of the formula METHOD F By reacting an a-amino-cyanoalkane of the formula NEG-CH-B1 .41 32 R3 (XII) wherein R R and R have the same meanings as in Formula I, with a benzene compound of the formula (XIII) wherein R, has the same meaning as in Formula I, in the presence of a Friedel-Crafts catalyst, such as aluminum chloride, and subsequently hydrolyzing the ketimine reaction product.

The reaction between compounds XII and XIII may be carried out in the presence of a solvent customarily used for this type of reaction, such as nitrobenzene; when aluminum chloride is used as the catalyst, it proceeds smoothly at slightly elevated temperatures while introducing hydrogenchloride into the reaction mixture for several hours.

The compounds according to the present invention have optically active centers and therefore occur as racemic mixtures which may be divided into the respective optically active antipode components in customary fashion, such as by fractional crystallization of their diastereomeric salts with dibenzoyl-d-tartaric acid.

The compounds embraced by Formula I are organic bases and may, if desired, be converted into their nontoxic, pharmacologically acceptable acid addition salts by conventional methods, such as by dissolving the free base in a suitable solvent and acidifying the solution with the desired inorganic or organic acid, Examples of inorganic and organic acids which will form non-toxic, pharmacologically acceptable acid addition salts with the basic compounds of the Formula I above are hydrochloric acid, sulfuric acid, acetic acid, tartaric acid, maleic acid, sulfaminic acid, S-chlorotheophylline and the like.

The following examples further illustrate the present invention and will enable others skilled in the art to understand it more completely. It should be understood, however, that the invention is not limited solely to the particular examples given below.

Example 1 Preparation of 1 (p methoxyphenyl)-2-ethylaminobutanone-(l) and its hydrochloride by Method A.--31 gm. (0.12 mol) of l-(p-methoxy-phenyl)-2-bromo-butanone-(1) were dissolved in cc. of absolute benzene, and the resulting solution was cooled to 5 C. Thereafter, 18 gm. (0.4 mol) of ethylamine were added to the solution, and the mixture was allowed to stand overnight at room temperature. Subsequently, the reaction mixture was refluxed on a water bath for three hours, allowed to cool, admixed with ether, and washed with water. The organic phase was dried over magnesium sulfate, evaporated, and the residue, l-(p-methoxyphenyl)-2-ethylamino-butanone-(l), was dissolved in ether. The resulting solution was acidified with ethereal hydrochloric acid, and the precipitate formed thereby was collected and recrystallized from ethanol. 19.5 gm. (63% of theory) of a compound having a melting point of 223224 C. were obtained, which was identified to be the hydrochloride of l-(p-methoxy-phenyl)-2-ethylamino-butanone-( l) of the formula i CHgOQ-G-(EH-OIIz-ClIs-HCI NH C 2H5 Example 2 ll C-OB-OHz-CH:

NED-CH3 was prepared from l-(o-methoxy-phenyl)-2-bromo-butanone-( 1) and methylamine. Its hydrochloride had a melting point of -163 C.

Example 3 Using a procedure analogous to that described in Example 1, l-(o-methoxy-phenyl)-2-ethylamino-butanone- (l) was prepared from 1-(o-methoxy-phenyl)-2-brom0- butanone-(l) and ethylamine. Its hydrochloride had a melting point of 172-174 C.

Example 4 Example 5 Using a procedure analogous to that described in Example 1, l-(m-methoxy-phenyl) 2 methylamino-butanone-(1) of the formula II @c-prr-cm-cm was prepared from l-(m-methoxy-phenyl)-2-bromo-butanone-(1) and methylamine. Its hydrochloride had a melt ing point of 210-2l3 C.

Example 6 Using a procedure analogous to that described in Example 1, l-(m-methoxy-phenyl)-2-ethylamino-butanone- 1) was prepared from l-(m-methoxy-phenyl)-2-bromobutanone-(l) and ethylamine. Its hydrochloride had a melting point of 23 7240 C.

Example 7 Using a procedure analogous to that described in Example 1, 1-(m-methoxy-phenyl)-2-n-propylamino-butanone-(1) was prepared from 1-(m-methoXy-phenyl)-2- bromo-butanone-(l) and n-propylamine. Its hydrochloride had a melting point of 210-213 C.

Example 8 Using a procedure analogous to that described in Example 2, 1-(m-methoxy-phenyl)-2-isopropylamino-butanone-(1) was prepared from 1-(m-methoxy-phenyl)-2- bromo-butanone-(l) and isopropylamino. Its hydrochloride had a melting point of 225230 C.

Example 9 Using a procedure analogous to that described in Example 1, l-(p-methoxy-phenyl)-2-methylamino-butanone- (l) was prepared from 1-(p-methoxy-phenyl)-2-bromobutanone-(l) and methylamine. Its hydrochloride had a melting point of 2152l7 C.

Example 10 Using a procedure analogous to that described in Example 1, l (p-methoxy-phenyl)-2-npropylamino-butanone-(1) was prepared from 1-(p-methoxy-phenyl)-2- bromo-butanone-(l) and n-propylamine. Its hydrochloride had a melting point of 187189 C.

Example 11 Using a procedure analogous to that described in Example 1, 1 (p-methoxy-phenyl)-2-isopropylamino-butanone-(1) was prepared from 1-(p-methoxy-phenyl)-2- bromo-butanone-( 1) and isopropylamine. Its hydrochloride had a melting point of 209211 C.

Example 12 Using a procedure analogous to that described in Example 1, l-(o-methoxy-phenyl)-2-isopropylamino-pentanone-( 1) of the formula CHgO NHCH(CH3)2 was prepared from 1-(o-methoxy-phenyl)-2-bromo-pentanone-(1) and isopropylamine. Its hydrochloride had a melting point of 178179 C.

Example 13 Using a procedure analogous to that described in Example 1, 1 (m-methoxy-phenyl)-2-methylamino-pentanone-( 1) was prepared from 1-(m-methoxy-pheny1)-2- bromo-pentanone-( 1) and methylamine. Its hydrochloride had a melting point of 195 C.

Example 14 Using a procedure analogous to that described in Example 1, 1- (m-methoxy-phenyl -2-n-propylamino-pentanone-(1) was prepared from 1-(m-methoxy-phenyl)-2- bromo-pentanone-(l) and n-propylamine. Its hydrochloride had a melting point of 202205 .5 C.

Example 15 Using a procedure analogous to that described in Example 1, l-(m-methoxy-phenyl)-2-isopropylamino-pentanone-( 1) was prepared from 1-(m-methoxy-phenyl)-2- bromo-pentanone-(l) and isopropylamine. Its hydrochloride had a melting point of 205206 C.

Example 16 Using a procedure analogous to that described in Example 1, 1 (p-methoxy-phenyl)-2-methylamino-pentanone-(1) was prepared from 1-(pmethoxy-phenyl)-2- bromo-pentanone-(l) and methylamine. Its hydrochloride had a melting point of 201-205 C.

Example 17 Using a procedure analogous to that described in Example 1, 1-(p-methoxy-phenyl)-2-ethylamino-pentanone- 1) was prepared from 1-(p-methoxy-phenyl)-2-bromopentanone-( 1) and ethylamine. Its hydrochloride had a melting point of 216221 C.

Example 18 Using a procedure analogous to that described in Example 1, 1 (p-methoxy-phenyl)-2-n-propylamino-pentanone-( 1) was prepared from 1-(p-methoxy-phenyl)-2- bromo-pentanone-(l) and n-propylamine. Its hydrochloride had a melting point of 190.5 to 193.5 C.

Example 19 Using a procedure analogous to that described in EX- ample 1, 1-(p-methoxy-phenyl)-2-isopropylamino-pentanone-(l) was prepared from 1-p-methoxy-penyl)-2- bromo-pentanone-(l) and isopropylamine. Its hydrochloride had a melting point of 217.5221 C.

Example 20 Using a procedure analogous to that described in EX- ample 1, 1-(p-methoxy-phenyl) 2 sec.butylamino pentanone-( 1) was prepared from 1-(p-methoxy-phenyl)2- bromo-pentanone-(1) and sec.butylamine. Its hydrochloride had a melting point of 203207 C.

Example 21 Using a procedure analogous to that described in Ex ample 1, 1-(p-methoxy-phenyl)-2-dimethylamino-pen tanone-( 1) was prepared from 1-(p-methoxy-phenyl)-2- bromo-pentanone-(l) and dimethylamine. Its hydrochlo ride had a melting point of 187191.5 C.

The compounds according to the present invention, that is, the racemates and optically active antipodes of those embraced by Formula I above as well as non-toxic acid addition salts of the racemates and optically active antipodes, have useful pharmacodynamic properties. More particularly, they exhibit very effective central nervous system stimulating activities in warm-blooded animals, such as mice.

The central nervous system stimulating activity and toxicity of the compounds according to the present invention Were ascertained by means of the following standard pharmacological tests:

(1) Central nervous system stimulating activity- Gradually increasing doses (5, 10, 15, 20, 25 and 30 mgm./kg.) of the compounds under investigation were administered subcutaneously in solution in distilled water to groups of five adult laboratory mice each, while the animals of a group of control animals received an equal volume of an aqueous 0.9% solution of sodium chloride by subcutaneous injection. Thereafter, the median elr'ec tive does (ED that is, the dose which produces nervous stimulation in 50% of the test animals, was determined by the method of Karber, as described in Arch. Exp. Path. u. Pharmakol. 162, 480 (1931).

(2) Txicity.The toxicity of the compounds under investigation was determined in the same maner as the central nervous system stimulating activity, except that higher doses (100, 200, 300 and 400 mgm./kg.) of the compounds were administered to the animals by subcutaneous injection. The median lethal dose (LD was determined by counting the number of animals which died within 24 hours after administration of each dose and calculating from the values thus obtained the dose which causes death in 50% of the animals, pursuant to K'zirber (loc. cit).

Finally, the therapeutic index (TI), that is, the ratio LD /ED was calculated for each test compound.

The following table shows the results obtained:

For pharmaceutical purposes the compounds according to the present invention are administered to warmblooded animals orally or parenterally as active ingredients in conventional dosage unit compositions, that is, compositions in dosage unit form consisting essentially of an inert pharmaceutical carrier and one dosage unit of the active ingredient, such as tablets, coated pills, sustained release tablets, capsules and the like. One oral dosage unit of the compounds according to the present invention is from 0.0166 to 2.5 mgm./kg. body weight, preferably 0.083 to 1.25 mgm./ kg. One parenteral dosage unit is from 0.005 to 0.84 mgm./kg, preferably 0.0166 to 0.34 mgm./kg.

The following examples illustrate a few dosage unit compositions comprising a compound of the invention as an active ingredient and represent the best mode contemplated of putting the invention to practical use. The parts are parts by weight, unless otherwise specified.

Example 22 Tablets-The tablet composition was compounded from the following ingredients:

Compounding pr0cedure.The butanone compound, the lactose and a substantial portion of the corn starch and of the silicic acid were thoroughly admixed with each other, and the mixture was moistened with an aqueous 10% solution of the gelatin. The moist mass was forced through a 1.5 min-mesh screen, the moist granulate obtained thereby was dried for about twelve hours at 45 C., and the dry granulate was again passed through the screen. Thereafter, the granulate was thoroughly admixed with the remainder of the corn starch and of the silicic acid as Well as with the magnesium stearate, and the resulting mixture was pressed into 450 mgm. tablets. Each tablet contained 35 mgm. of the butanone compound and, when administered perorally to a warm-blooded animal of about 60 kg. body weight in need of such treatment, produced very good CNS stimulating effects.

Lactose, pulverized 8.0 Corn starch 8.0 Talcum 8.0 Magnesium stearate 1.0

Total 50.0

Compounding procedure.--The hydrogenated castor oil was heated to its melting point, the butanone compound was uniformly distributed therein, and the mixture was stirred until it had cooled to about room temperature. The solidified mass was then comminuted to a particle size of 1.5 mm., admixed with a filler granulate consisting of the lactose and the corn starch, and the mixture was uniformly admixed with the talcum and the magnesium stearate. The resulting composition was pressed into 50 mgm. tablets. Each tablet contained 3 mgm. of the pentanone compound and, when adminis tered perorally to a warm-blooded animal of about 60 kg. body Weight in need of such treatment, produced very good CNS stimulating effects.

Example 24 Hypodermic s0luti0n.The solution was compounded from the following ingredients:

1 (p methoxy phenyl)-2-ethylamino-buta- Compounding procedure.-The butanone compound and the EDTA salt were dissolved in the distilled water, the solution was filtered until free from suspended particles, and the filtrate was filled into 2-rn1. ampules which were then sterilized and sealed. Each ampule contained 30 mgm. of the butanone compound, and when the contents thereof were administered intravenously to a warmblooded animal of about 60 kg. body weight in need of such treatment, very good CNS stimulating eifects were obtained.

Although the above dosage unit composition examples illustrate the use of only three specific compounds of the present invention as active ingredients, it should be understood that any of the other compounds embraced by Formula I or an optical antipode thereof, or a non-toxic acid addition salt of either of these may be substituted for the particular compounds illustrated in Examples 22 through 24. Moreover, the amount of active ingredient in the above illustrative dosage unit compositions may be varied within the dosage unit limits set forth above, and the amounts and nature of the inert carrier components may be varied to meet particular requirements.

9 10 We claim: 4. A compound according to claim 1, wherein R and 1. A racemic mixture of a compound of the formula R are ethyl, and R is hydrogen.

5. A compound according to claim 1, wherein R is ethyl, R is isopropyl, and R is hydrogen.

1 CH CCHR I References Cited UNITED STATES PATENTS 1,767,423 6/1930 Adams 260570.6 2,155,194 4/1939 Kamlet 26O570 .5 wherein 10 2,854,483 9/1958 Langis et al. 260-570.6 1 is straight-chain alkyl of 2 to 4 carbon atoms, 3,082,255 3/1963 Stevens et al. 260-5705 2 i alkyl 0f 1 to 4 Carbon m and 3,225,096 12/1965 Mills et al. 260570.5 R is hydrogen or methyl, 3,254,124 5/1966 Stevens 260570.5 an optically active antipode component thereof, or a non- 15 3,340,305 9/1967 Jahn 26O 570'5 X toxic, pharmacologically acceptable acid addition salt of said racemic mixture or of said optically active antipode. ROBERT HINES Pnmary Exammer 2. A compound according to claim 1, wherein R and R are ethyl, and R is hydrogen.

3. A compound according to claim 1, wherein R is 20 260348, 570.6, 465.5, 566, 482, 561, 501.17, 253, 592; ethyl, R is methyl, and R is hydrogen. 424330, 253

CERTIFICATE OF CORRECTION Patent No- 3 .492 .351.

Dated January 27. 197

Inventor(s) ET It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

Col. 2, Formula VII R should be --R Col. 5, line 5 (-omet'hoxy-" should be (-o-methoxy- Col. 5, Example 5 CH-CH should be -CH-CH formula NH-CI-Ig DIE-CH Col. 5, line #2 "isopropylamino" should be --1sopropy1am:|

Col. 6, line 49 "l-p-methoxy" should be l(p-methoxy Col. 7, line 17 "mener" should be manner SIGNED AND SEALED 30l970 EAL) Attest:

Edward M. much,

Atteating Offioer m. .m.

fiominioner of Patents 

